Everything You Need to Know About Using Tretinoin to Treat Acne

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With the sheer number of acne treatments out there, it seems daunting at best and impossible at worst to discern which one is right for you and your skin. While consulting a dermatologist is the one and only way you can know for sure, it helps to do a little research on your own—or, in this case, a little reading on your own, because we have the research part covered. Whether it's spironolactone, various forms of birth control, or tretinoin (which is the medication we're concerned with today), our goal is to lay out the pros and cons of each, in an easy, fuss-free way.

So let's get down to brass tacks, shall we? Tretinoin is a fairly common medication prescribed by dermatologists to treat and prevent chronic acne. Take it from board-certified dermatologist and founder and CEO of Curology Dr. David Lortscher: "Tretinoin is one of the most powerful and widely researched vitamin A derivatives (retinoids). Tretinoin is considered the benchmark ingredient among dermatologists for treating acne, wrinkles, fine lines, and uneven skin tone."

Keep scrolling to learn almost everything you'd ever need to know about taking tretinoin for acne.


  • Type of ingredient: retinoid
  • Main benefits: treats acne; minimizes and prevents fine lines and wrinkles; evens out skin tone
  • Who should use it: in general, anyone with acne-prone skin or aging concerns; tretinoin is not recommended for pregnant people or those with rosacea
  • How often can you use it: Tretinoin can be used up to once per day depending on skin sensitivity and should be applied at night.
  • Works well with: moisturizers
  • Don’t use with: other exfoliators such as benzoyl peroxide, glycolic acid, and astringents, which may result in dryness and irritation

What Is Tretinoin?

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Thanks to Lortscher, we already know that tretinoin is a derivative of vitamin A. This classifies it as a retinoid. What is a retinoid, you ask? According to Estee Williams, a cosmetic and medical dermatologist based in New York City, "Retinoid is just an umbrella term for many forms of vitamin A, with tretinoin and retinol being two examples (other examples include retinaldehyde and tazarotene). All of these differ from one another by their chemical and molecular structure, and the receptors that they bind within the cell; thus, their ultimate effects—and side effects—are slightly different."

This means that, like retinol and other retinoids, it can do more than just treat breakouts. It's also proven to treat signs of aging like fine lines and wrinkles, as well as hyperpigmentation and sun damage. It's clear why some people refer to it as a skincare wonder, of sorts. 

Benefits of Tretinoin for Acne

  • Exfoliates: "Tretinoin increases cellular turnover and chemically exfoliates the top layers of our skin," dermatologist Anna Karp explains.
  • Calms inflammation: "Tretinoin lessens the shedding of dead skin cells into the pore/hair follicle and decreases inflammation," says Karp.
  • Unclogs pores: "Acne is a multi-factorial disease with increased dead skin cells filling up in our pores causing comedones and inflammation. Bacteria often colonize the pore, leading to worse acne," says Karp. Tretinoin helps break down those comedones.
  • Fights signs of aging: "Decades of research confirm tretinoin as the 'gold standard' in topical treatment for fighting acne and clogged pores, as well as reducing fine lines, mitigating unwanted pigmentation, and improving skin texture," says Lortscher.

Tretinoin vs. Retinol

In the United States, tretinoin is available only by prescription from a healthcare professional. So is it smarter to skip the doctor and pharmacy visits and hit Sephora for an OTC retinol product instead?

Not exactly, Lortscher says. Tretinoin and retinol both fall into the retinoid category, so they're aces for treating acne and the signs of aging. But tretinoin is a "more potent retinoid" and works much, much more effectively than non-prescription retinol. "Although strengths cannot be compared across the board, it has been observed that retinol is roughly 20 times less potent than tretinoin," Lortscher explains.

If you're not jazzed about jumping through the hoops of the healthcare system, and have mild acne or very sensitive skin, choosing retinol over tretinoin may make more sense for you. But if you want maximum results, consider discussing tretinoin with your doctor.

Side Effects of Tretinoin

"The main side effects are dryness, so I often recommend moisturizing with the product," Karp says. "I think applying the moisturizer followed by the tretinoin is the easiest way." 

According to our experts, tretinoin is suitable for most people; the only people who should be wary of it are those who have extremely sensitive skin, rosacea, or who are or might become pregnant. It may prove too harsh for the former skin conditions, and even though it's a topical medication, pregnant women are advised against using it.

If you don't have extremely sensitive skin, severe rosacea, and you're not pregnant, tretinoin might be for you—especially if you suffer from a specific type of acne. "In my opinion, tretinoin is a great option for comedonal acne (blackheads and whiteheads) since it helps exfoliate and prevent plugging," Williams says. "We now have a newly FDA-approved topical tretinoin in lotion form, which should help manage the dryness that can often happen when starting a retinoid."

How to Use It

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When it comes down to it, tretinoin is unique in the way that it approaches acne. Since it's first and foremost a powerful exfoliating force, it differs from other common acne medications in that it's used topically as opposed to taken internally. Other buzzy acne medications, such as spironolactone, are ingested.

"These are two very different medications," Lortscher warns. "Spironolactone is an oral medication that can be used to treat acne in women, while tretinoin is used topically to treat acne and clogged pores. Spironolactone was developed as a diuretic (water pill) and an antihypertensive, increasing the output of urine and lowering high blood pressure. It does this by blocking aldosterone, a hormone that regulates salt and water balance. It also blocks the effects of male hormones in the skin, decreasing sebum (oil) production and helping acne. Because it is an anti-androgen, spironolactone is not used to treat acne in men."

Adapalene is another buzzy anti-acne ingredient. Like tretinoin, it's a retinoid, and according to Karp, it's equally as effective. "The great thing is that now adapalene is over the counter, so patients can buy it without a prescription." She recommends Proactiv Adapalene Gel ($36). "This is a great option for someone who wants a prescription-strength product (ideal strength for best results) but wants to avoid going to the doctor or has issues with insurance coverage. I do recommend everyone see a professional if they have moderate to severe acne to optimize their results."

The Best OTC Acne-Fighting Products

differin gel
Differin Adapalene Gel $12

Differin is an over-the-counter adapalene gel. The instructions say you can apply this formula as an all-over or spot treatment, but dermatologist Rachel Nazarian, MD, advises against spot treating with adapalene. "Often it can be too irritating to use as a localized treatment," she says. Instead, apply a pea-sized amount in an even layer all over your face as a first step after cleansing.

peace out dots
Peace Out Acne Healing Dots $19

These innovative pimple patches are tiny stickers that you place on a breakout to speed up healing and decrease inflammation and redness in a matter of hours.

m. badescu
Mario Badescu Drying Lotion $17

We don't think there's one acne product more iconic than this one by Mario Badescu. Use it as a spot treatment to dry out blemishes overnight. Celebrities like Lili Reinhart, Bella Hadid, and Rosie Huntington-Whiteley swear by it. 

Article Sources
Byrdie takes every opportunity to use high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial guidelines to learn more about how we keep our content accurate, reliable and trustworthy.
  1. Sumita JM, Leonardi GR, Bagatin E. Tretinoin peel: a critical viewAn Bras Dermatol. 2017;92(3):363-366. doi:10.1590/abd1806-4841.201755325

  2. Ho ET, Trookman NS, Sperber BR, et al. A randomized, double-blind, controlled comparative trial of the anti-aging properties of non-prescription tri-retinol 1.1% vs. prescription tretinoin 0.025%. J Drugs Dermatol. 2012;11(1):64-69.

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